Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis
نویسندگان
چکیده
منابع مشابه
Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis
Message-specific translational control is required for gametogenesis. In yeast, the RNA-binding protein Rim4 mediates translational repression of numerous mRNAs, including the B-type cyclin CLB3, which is essential for establishing the meiotic chromosome segregation pattern. Here, we show that Rim4 forms amyloid-like aggregates and that it is the amyloid-like form of Rim4 that is the active, tr...
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ژورنال
عنوان ژورنال: Cell
سال: 2015
ISSN: 0092-8674
DOI: 10.1016/j.cell.2015.08.060